SCIENCE CHINA Chemistry, Volume 61, Issue 3: 266-275(2018) https://doi.org/10.1007/s11426-017-9127-y

The designing strategies of graphene-based peroxidase mimetic materials

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  • ReceivedJul 5, 2017
  • AcceptedAug 24, 2017
  • PublishedDec 27, 2017


Natural enzymes have been praised highly as ideal catalysts, presumably owing to their remarkable advantages of high efficiency, high selectivity, and mild reaction conditions. The reports of chemical simulation and systematic synthesis of natural enzymes such as peroxidase (POD) are rare because of their complex biological structures. POD represents a large family of oxidoreductases and offers a wide range of applications in many fields of science. Recent advance in the fusion of nanomaterial, catalysis, and biochemistry has inspired the development of artificial enzymes implemented with desired catalytic features of natural enzymes. Herein, we review the redox chemistry of POD and compare its catalytic performance to graphene-based nanomaterials (G-NMs) as POD mimetic nanoenzymes bases on catalytic center, binding site, and carrier function. Based on the viewpoints of stereo chemistry and molecular kinetic and dynamics in heterogeneous system, we evaluate and compare the suitability of different NMs as artificial enzyme constituent. We propose that reevaluates design strategies of graphene-based peroxidase (G-POD) mimetic materials and emphasizes on their selectivity (role as catalytic center, binding site, or carrier) is of uttermost.

Funded by

Ministry of Science and Technology of Taiwan(MOST104-2113-M-007-008-MY3)

National Tsing Hua University(Foxconn Company Scholarship)


This work was supported by the Ministry of Science and Technology of Taiwan (MOST104-2113-M-007-008-MY3), and the Taiwan Tsing Hua University (Foxconn Company Scholarship).

Interest statement

The authors declare that they have no conflict of interest.


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