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SCIENCE CHINA Chemistry, Volume 61, Issue 7: 763-764(2018) https://doi.org/10.1007/s11426-018-9255-7

Drugging the undruggable molecules by a DNA nanorobot

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  • ReceivedMar 12, 2018
  • AcceptedApr 8, 2018
  • PublishedApr 28, 2018

Abstract

There is no abstract available for this article.


Interest statement

The authors declare that they have no conflict of interest.


References

[1] Li S, Jiang Q, Liu S, Zhang Y, Tian Y, Song C, Wang J, Zou Y, Anderson GJ, Han JY, Chang Y, Liu Y, Zhang C, Chen L, Zhou G, Nie G, Yan H, Ding B, Zhao Y. Nat Biotechnol, 2018, 36: 258-264 CrossRef PubMed Google Scholar

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  • Figure 1

    Therapeutic mechanism of DNA nanorobot within tumor vessels. (a) Thrombin molecules are caged inside the nanorobot in an inactive state. Addition of nucleolin-targeting DNA aptamers closes the thrombin-loaded DNA plates into the final barrel-like DNA nanorobots. Upon binding to nucleolin, which is overexpressed on the surfaces of tumor endothelial cells, closed nanorobot opens to expose the encapsulated thrombin, which initiates localized coagulation at the tumor site. (b) An overall process [1] (color online).

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