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  • ReceivedNov 28, 2018
  • AcceptedNov 29, 2018
  • PublishedDec 7, 2018

Abstract

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.


Funded by

the National Natural Science Foundation of China(11621505,11435002,31671016)


Acknowledgment

This work was supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016).


Interest statement

The authors declare that they have no conflict of interest.


Contributions statement

These authors contributed equally to this work.


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