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SCIENCE CHINA Life Sciences, Volume 60, Issue 3: 326-328(2017) https://doi.org/10.1007/s11427-016-0373-3

Will cancer cells be defeated by sodium bicarbonate?

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  • ReceivedNov 30, 2016
  • AcceptedDec 6, 2016
  • PublishedJan 4, 2017

Abstract

There is no abstract available for this article.


Funded by

Breast Cancer Research Foundation and the National Institutes of Health to M.I.G.(R01CA089481,R01CA149425)

DOD IDEA grant to S.S.(W81XWH-15-1-0362)


Acknowledgment

This work was supported by the Breast Cancer Research Foundation and the National Institutes of Health to Mark I. Greene (R01CA089481, R01CA149425), and the Department of Defense Lung Cancer Research Program Idea Development Award grant to Sunil Singhal (W81XWH-15-1-0362). Mr. Cameron Jeffers kindly read the manuscript and provided discussions and suggestions.


Interest statement

The author(s) declare that they have no conflict of interest.


References

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  • Figure 1

    (Color online) Glycolysis in cancer cells. Cancer cells are dependent on glycolysis for energy and produce lactate and protons (H+) as metabolites, which are pumped out of cells and create an acidic immune-suppressive tumor microenvironment. By neutralizing H+, the sodium bicarbonate in the TILA-TACE procedure was shown to improve the clinical outcomes of TACE.

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