SCIENCE CHINA Life Sciences, Volume 61, Issue 3: 348-350(2018) https://doi.org/10.1007/s11427-017-9149-0

Human PIWI (HIWI) is an azoospermia factor

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  • ReceivedJul 10, 2017
  • AcceptedJul 20, 2017
  • PublishedAug 10, 2017


There is no abstract available for this article.


Acknowledgements We thank Jeremy Allen, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Interest statement

Compliance and ethics The author(s) declare that they have no conflict of interest.


[1] de Koning A.P.J., Gu W., Castoe T.A., Batzer M.A., Pollock D.D.. Repetitive Elements May Comprise Over Two-Thirds of the Human Genome. PLoS Genet, 2011, 7: e1002384 CrossRef PubMed Google Scholar

[2] Deng W., Lin H.. miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis. Dev Cell, 2002, 2: 819-830 CrossRef Google Scholar

[3] Gou L.T., Kang J.Y., Dai P., Wang X., Li F., Zhao S., Zhang M., Hua M.M., Lu Y., Zhu Y., Li Z., Chen H., Wu L.G., Li D., Fu X.D., Li J., Shi H.J., Liu M.F.. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell, 2017, 169: 1090-1104.e13 CrossRef PubMed Google Scholar

[4] Iwasaki Y.W., Siomi M.C., Siomi H.. PIWI-Interacting RNA: Its Biogenesis and Functions. Annu Rev Biochem, 2015, 84: 405-433 CrossRef PubMed Google Scholar

[5] Lu L.Y., Wu J., Ye L., Gavrilina G.B., Saunders T.L., Yu X.. RNF8-Dependent Histone Modifications Regulate Nucleosome Removal during Spermatogenesis. Dev Cell, 2010, 18: 371-384 CrossRef PubMed Google Scholar

[6] Matsumoto N., Nishimasu H., Sakakibara K., Nishida K.M., Hirano T., Ishitani R., Siomi H., Siomi M.C., Nureki O.. Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA. Cell, 2016, 167: 484-497.e9 CrossRef PubMed Google Scholar

[7] Pillai R.S., Chuma S.. piRNAs and their involvement in male germline development in mice. Dev Growth Differentiation, 2012, 54: 78-92 CrossRef PubMed Google Scholar

[8] Roovers E.F., Rosenkranz D., Mahdipour M., Han C.T., He N., Chuva de Sousa Lopes S.M., van der Westerlaken L.A.J., Zischler H., Butter F., Roelen B.A.J., Ketting R.F.. Piwi Proteins and piRNAs in Mammalian Oocytes and Early Embryos. Cell Rep, 2015, 10: 2069-2082 CrossRef PubMed Google Scholar

[9] Sasaki T., Shiohama A., Minoshima S., Shimizu N.. Identification of eight members of the Argonaute family in the human genome☆. Genomics, 2003, 82: 323-330 CrossRef Google Scholar

[10] Williams Z., Morozov P., Mihailovic A., Lin C., Puvvula P.K., Juranek S., Rosenwaks Z., Tuschl T.. Discovery and Characterization of piRNAs in the Human Fetal Ovary. Cell Rep, 2015, 13: 854-863 CrossRef PubMed Google Scholar

[11] Zhao S., Gou L.T., Zhang M., Zu L.D., Hua M.M., Hua Y., Shi H.J., Li Y., Li J., Li D., Wang E.D., Liu M.F.. piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis. Dev Cell, 2013, 24: 13-25 CrossRef PubMed Google Scholar

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