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SCIENCE CHINA Life Sciences, Volume 61, Issue 4: 392-399(2018) https://doi.org/10.1007/s11427-017-9292-7

Theranostical application of nanomedicine for treating central nervous system disorders

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  • ReceivedNov 5, 2017
  • AcceptedJan 10, 2018
  • PublishedApr 2, 2018

Abstract

The primary reason for the failure of traditional medicine in treating the disorders of the central nervous system (CNS) is the obstruction to traverse the blood-brain barrier (BBB). Due to the unique physiochemical properties of nanoparticles, they can preferably help deliver drugs passing through the BBB. Researchers have been investigating the capacity of multifunctional nanomaterials as theranostical agents. However, some of the studies have reported controversial results, which might be due to different schematic designs, including size, surface charge, and shape. This review summarizes the applications of nanoparticles to overcome the BBB or contribute to improving the diagnostic and therapeutic effects in CNS diseases.


Funded by

the National Natural Science Foundation of China(31771031,81701829)


Acknowledgment

This work was supported by the National Natural Science Foundation of China (31771031 and 81701829).


Interest statement

The author(s) declare that they have no conflict of interest.


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  • Figure 1

    (Color online) The diagnosis and treatment effects of Congo red/rutin-MNPs in Alzheimer’s disease. A, The preparation of Congo red/rutin-MNPs. B, Schematic interpretation of Congo red/rutin-MNPs in vivo. After the penetration of Congo red/rutin-MNPs through the BBB, they can be specifically detected through amyloid plaques and serve as antioxidants preventing neuronal loss due to oxidative stress (Hu et al., 2015).

  • Figure 2

    (Color online) Cur-PLGA-NPs reverse learning and memory deficits in Alzheimer’s disease. A and B, Photomicrographs showing immunostaining of BrdU cells in the hippocampus. After one week of Aβ protein stereotaxic injection, rats were treated with BC and Cur-PLGA-NPs. C and D, Immunofluorescence analysis of matured neurons co-labeled with β-tubulin (red: marker for mature neurons) and BrdU (green) in the hippocampus. Scale bar, 20 μm. E, Learning and memory defects were recovered in the Cur-PLGA-NP-treated group compared with that in control rats. Values are expressed as mean±SEM (n=6 rats/group). *, P<0.05 (Tiwari et al., 2014).

  • Figure 3

    (Color online) Schematic illustration of nanoparticles applied for disorders of the central nervous system (Li et al., 2014).

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