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SCIENCE CHINA Life Sciences, Volume 62, Issue 1: 12-21(2019) https://doi.org/10.1007/s11427-018-9334-2

Primate stem cells: bridge the translation from basic research to clinic application

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  • ReceivedApr 15, 2018
  • AcceptedMay 10, 2018
  • PublishedAug 9, 2018

Abstract

A growing body of literature has shown that stem cells are very effective for the treatment of degenerative diseases in rodents but these exciting results have not translated to clinical practice. The difference results from the divergence in genetic, metabolic, and physiological phenotypes between rodents and humans. The high degree of similarity between non-human primates (NHPs) and humans provides the most accurate models for preclinical studies of stem cell therapy. Using a NHP model to understand the following key issues, which cannot be addressed in humans or rodents, will be helpful for extending stem cell applications in the basic science and the clinic. These issues include pluripotency of primate stem cells, the safety and efficiency of stem cell therapy, and transplantation procedures of stem cells suitable for clinical translation. Here we review studies of the above issues in NHPs and current challenges of stem cell applications in both basic science and clinical therapies. We propose that the use of NHP models, in particular combining the serial production and transplantation procedures of stem cells is the most useful for preclinical studies designed to overcome these challenges.


Funded by

the Yunnan National Key R&D Program and the National Natural Science Foundation of China(31760268)


Acknowledgment

This work was supported by the Yunnan National Key R&D Program and the National Natural Science Foundation of China (31760268).


Interest statement

The author(s) declare that they have no conflict of interest.


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  • Figure 1

    The pluripotency of primate pluripotent stem cells. Primate pluripotent stem cells undergo three different states (naive, formative and primed) over development. ICM, inner cell mass; EPI, epiblast; AME, amniotic epithelium.

  • Figure 2

    The summary of NHP applications in developing procedures of stem cell therapy for clinical translation.

  • Table 1   Some key scientific questions of primate pluripotent stem cells. The labels “+” indicate that the question has been solved. The labels “?” indicate that the question has not been solved

    Species

    PSCs

    Naive PSCs

    Formative PSCs

    Chimera competency

    Germline transmission

    Tetraploid complementation

    Mice

    +

    +

    +

    +

    +

    +

    Rat

    +

    +

    ?

    +

    +

    +

    Monkey

    +

    +/?

    +/?

    +

    +/?

    ?

    Human

    +

    +/?

    ?

     

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