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SCIENCE CHINA Information Sciences, Volume 63 , Issue 7 : 170103(2020) https://doi.org/10.1007/s11432-019-2847-8

Neuroimaging and intervening in memory reconsolidation of human drug addiction

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  • ReceivedNov 30, 2019
  • AcceptedMar 18, 2020
  • PublishedMay 29, 2020

Abstract

Reconsolidation refers to memory reprocessing when consolidated memory is being recalled and restored. Importantly, as memory is being recalled, it could further modify past memories. Memory reconsolidation has been identified as a critical role in various types of mental disorders, in particular drug addiction. In this review, we first review earlier studies related to reconsolidation. Secondly, we characterize memory reconsolidation processing in human brain via neuroimaging studies. Then we focus on the role of reconsolidation and reconsolidation-based interventions in drug addiction. Finally, we highlight the potentials of combining reconsolidation-based interventions and neuroimaging techniques as a therapeutic tool in drug addiction.


Acknowledgment

This work was supported by National Key Basic Research Program (Grant Nos. 2016YFA0400900, 2018YFC0831101), National Natural Science Foundation of China (Grant Nos. 71942003, 31771221, 61773360, 71874170), School Foundation of Anhui Medical University (Grant Nos. 2019xkj016, XJ201907), National Science Foundation for Young Scientists of China (Grant No. 31900766), Major Project of Philosophy and Social Science Research, Ministry of Education of China (Grant No. 19JZD010), Fundamental Research Funds for the Central Universities of China. A portion of the numerical calculations in this study were performed with the supercomputing system at the Supercomputing Centre of USTC.


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  • Figure 1

    (Color online) Current theory of memory formation and reconsolidation-based intervention. After encoding, memories undergo an initial unstable phase for a limited time, before stabilized through the consolidation phase. Consolidated memories may return to a labile state when they are retrieved or reactivated by a reminder, thus requiring the so-called reconsolidation. During the time-limited reconsolidation window, memories can be degraded, strengthened or updated by the inclusion of new information. Memories can be modified through behavioral means (e.g, interference, extinction), pharmacological agents (e.g, propranolol), or noninvasive brain stimulation (NIBS) techniques. Modified from [5,6].

  • Table 1  

    Table 1Neuroimaging and intervening techniques in memory reconsolidation studies

    fMRI NIBS
    AdvantagesHigh location resolution; Safe to human brain;
    Time-locked; Stimulate at depth precisely;
    Multiple analysis methods Without affecting other regions
    Current studies in exploring memory reconsolidation Observe the memory reconsolidation processing; Reveal the causal role of the target brain area;
    Evaluate the reconsolidation interfere effects; To modulate the memory reconsolidation process
    Explore the underlying mechanisms
    Future direction in drug addiction Explore the optimal retrieval-extinction paradigms; Examine the causal links between brain regions;
    Explore the underlying mechanisms; To modulate drug memory reconsolidation
    Measure the interfere effect

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