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SCIENCE CHINA Physics, Mechanics & Astronomy, Volume 61 , Issue 9 : 094601(2018) https://doi.org/10.1007/s11433-018-9239-9

An overview of healthcare monitoring by flexible electronics

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  • ReceivedApr 2, 2018
  • AcceptedMay 4, 2018
  • PublishedJul 10, 2018
PACS numbers

Abstract

Flexible electronics integrated with stretchable/bendable structures and various microsensors that monitor the temperature, pressure, sweat, bioelectricity, body hydration, etc., have a wide range of applications in the human healthcare sector. The science underlying this technology draws from many research areas, such as information technology, materials science, and structural mechanics, to efficiently and accurately monitor technology for various signals. In this paper, we make a classification and comb to the designs, materials, structures and functions of numerous flexible electronics for signal monitoring in the human healthcare sector. Some perspectives in this field are discussed in the concluding remarks.


Acknowledgment

This work was supported by the National Natural Science Foundation of China (Grant Nos. 11572323, 11772331, and 11302038), the Chinese Academy of Sciences via the “Hundred Talent Program”, the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB22040501), the State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology (Grant No. GZ1603), the State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology (Grant No. DMETKF2017008), and the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (CAST) (Grant No. 2015QNRC001).


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  • Figure 1

    (Color online) Categories of commonly detectable physiological signals.

  • Figure 2

    (Color online) (a) Different methods of temperature measurement; (b) optical images of a sensor array integrated on a thin elastomeric substrate [24]; (c) structure of an ultra-flexible temperature sensor on a breathable film [25].

  • Figure 3

    (Color online) (a) A temperature-sensor array and temperature distribution subjected to a heat source [31]; (b) temperature mapping of a fingertip and a rat lung [32]; (c) ultrathin injectable thermal sensors and a device injected into the myocardial tissue [33]; (d) schematic diagram of a flexible temperature sensor and the measured temperature distribution of the forehead [34].

  • Figure 4

    (Color online) (a) Pressure-sensitive structured PDMS films and the microstructured details; (b) pressure-response curves for different types of microstructured PDMS films [52]; (c) schematic of the fabrication of GO foam-based pressure sensor arrays; (d) pressure response of GO foams with different densities [53].

  • Figure 5

    (Color online) (a) Photos of the PDMS films with (top right) and without (bottom left) graphene layers and the pattern arrays; (b) stability of the sensor under loading cycles [57]; (c) cross-bar device structure of the pressure sensor based on the foam-like LSG [58]; (d) epitaxial structure, schematic configuration of the pressure sensors and the SEM image of ZnO nanorod array [59].

  • Figure 6

    (Color online) Some promising applications of pressure sensors. (a) Demonstration of blood pressure monitoring using a pressure sensor [60]; (b) real-time transient signals of pulse-wave velocity recorded at the femoral and carotid artery [61]; (c) photograph of a representative smart artificial skin with integrated stretchable sensors and actuators [62]; (d) sensors attached to the artery of the wrist and the signals [63]; (e) a sensor attached to the neck for recording human speech [64]; (f) schematic descriptions and the morphology of integrated energy devices [65]; (g) measurement of pulses on the identical contact sites of the neck [66].

  • Figure 7

    (Color online) Micrographs of various flexible electrodes in ECG devices. (a) Structural details with conductive foam [75]; (b) dome array on the electrode [76]; (c) three-layered structure of composite electrode and the SEM image of the middle layer (AgNWs) [77]; (d) a new graphene-coated textile electrode [78].

  • Figure 8

    (Color online) Typical commercial device-level flexible ECG measurement equipment. (a) ECG waveforms recorded by the device with CNT electrodes [79]; (b) effect of amperometric measurement on the ECG signals with and without sweat [80]; (c) apex cardiogram recording [81]; (d) flexible hybrid electronics and the heart rate during exercise [82].

  • Figure 9

    (Color online) (a) EEG measurement corresponding to eye opening and blinking [85]; (b) flexible EOG systems and signals recording [86]; (c) skin-like sensors and EMG signals [87]; (d) structure of the surface EMG sensor and the degree of conformal contact with different thicknesses of elastomers [88].

  • Figure 10

    (Color online) Various respiratory monitoring devices and sensors. (a) Thoracic volume variation during respiration and gesture recognition during sleep [93]; (b) schematic of the flow sensor and the simulated exhalation and inhalation processes [94]; (c) piezoelectric active sensor and the measurement of respiration rate [95].

  • Figure 11

    (Color online) Typical methods for measuring skin hydration.

  • Figure 12

    (Color online) Typical epidermal sensors for conformal skin hydration monitoring. (a) Soft, releasable connectors between the hydration sensors and the skin [109]; (b) a sensor integrated directly on the skin [111]; (c) photograph showing the AgNW sensor placed on the inner side of the forearm [112]; (d) sensor array for epidermal hydration mapping [113]; (e) optical micrograph of an epidermal hydration sensing system [114].

  • Figure 13

    (Color online) Measurement principles for sweat monitoring.

  • Figure 14

    (Color online) (a) Photograph of a wearable device integrating the multiplexed sensor array; (b) flattened flexible device and sensor array [136]; (c) schematic showing the simultaneous multiplexed monitoring of heavy metals [137]; (d) schematic illustration of a passive wireless capacitive sensor and the series of pictures of a sensor doped with a pH indicator [138].

  • Figure 15

    (Color online) (a) Optical image of the wearable sweat analysis patch and the characterization of individual sensors [142]; (b) schematic of the fabrication steps of the microfluidic chip and changes in location, temperature, pH, and sodium measurements [143].

  • Figure 16

    (Color online) (a) A liquid metal-based pressure sensor and the gesture recognition [145]; (b) multifunctional flexible platform and various signal measurements [146]; (c) a transparent and wearable force touch sensor array and its deformability [147]; (d) disintegrable electronics with different stages of disintegration [157].

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