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Facile synthesis of liposome/Cu2-xS-based nanocomposite for multimodal imaging and photothermal therapy

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  • AcceptedApr 3, 2015
  • PublishedApr 24, 2015

Abstract

A kind of multifunctional perfluoropentane (PFP) and ultrasmall Cu2-xS nanodots (u-Cu2-xS NDs) co-incorporated liposome (PFP@u-Cu2-xS NDs@liposome) nanocomposite has been facilely and successfully synthesized for enhanced ultrasound/infrared thermal/ photoacoustic multimodal imaging and photothermal therapy upon near infrared (NIR) laser irradiation. Such a liposome-based nanocomposite possesses a number of advantages, such as high dispersity and stability, excellent biocompatibility, small particle size (<100 nm), well-defined core/shell structure, strong NIR absorption and photo-triggered vaporization of PFP, etc. The detailed in vitro investigations demonstrate that the as-synthesized PFP@u-Cu2-xS NDs@liposome nanocomposite is capable of enhancing the contrasts of ultrasound/infrared thermal/photoacoustic multimodal imaging, and substantially improving the photothermal therapeutic efficacy. This novel liposome-based theranostic nanoplatform shows great potentials in the future cancer diagnosis and therapy.


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