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SCIENCE CHINA Materials, Volume 60, Issue 6: 504-510(2017) https://doi.org/10.1007/s40843-016-5163-4

Cell membrane-coated nanoparticles for tumor-targeted drug delivery

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  • ReceivedNov 27, 2016
  • AcceptedDec 20, 2016
  • PublishedJan 22, 2017

Abstract

Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemotherapy drugs with the well-known enhanced permeability and retention (EPR) effect. While conventional preparations of materials for nanoscale drug delivery system mainly focused on chemical synthesis, recently the combination of synthetic carrier and natural biomimetic carrier has gained more and more attention. As a new generation of biomimetic nanoparticles, cell membrane-coated nanoparticles combine the complex biological functions of natural membranes and the physicochemical properties of synthetic nanomaterials for a more effective drug delivery. Herein, we briefly review the recent advances on cell membrane-coated nanoparticles for tumor-targeted drug delivery via the prolonging systemic circulation lifetime and the active targeting effect. Since the preferential accumulation of cell membrane-coated nanoparticles in tumor site, they are able to improve the therapeutic efficacy of conventional chemotherapy drugs in antitumor treatment as well as to reduce the systemic toxicity. We also introduce a systematic targeted strategy for the promising application of this platform on brain tumors.


Funded by

National Basic Research Program of China(2013CB932500)

National Natural Science Foundation of China(81273458,81473149)


Acknowledgment

This work was supported by the National Basic Research Program of China (2013CB932500), and the National Natural Science Foundation of China (81273458 and 81473149).


Interest statement

The authors declare that they have no conflict of interest.


Contributions statement

Lu W proposed the review of tumor-targeted cell membrane-coated nanoparticles. Chai Z investigated literatures and wrote the paper. All authors contributed to the general discussion.


Author information

Zhilan Chai is a graduate student from the Department of Pharmaceutics, School of Pharmacy, Fudan University. She got her BCs degree in pharmacy from Fudan University (2011). In 2015, she joined Prof. Weiyue Lu’s group for further study. Her current research interests focus on red blood cell membrane coated-nanoparticle and its brain-targeting strategy.


Weiyue Lu is a professor at the Department of Pharmaceutics, School of Pharmacy, Fudan University, the Director of Key laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, China, the Principle Investigator of National Basic Research Program (973), and the Director of the Pharmaceutics Committee and Associate Director of the Nanomedicine Committee of Chinese Pharmaceutical Association (CPA). Professor Lu’s research focuses on brain, lymphatic system and its tumor targeting strategy and drug delivery system.


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