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SCIENCE CHINA Materials, Volume 62 , Issue 12 : 1831-1836(2019) https://doi.org/10.1007/s40843-019-9579-8

Polysaccharides-based nanohybrids: Promising candidates for biomedical materials

Zhiwen Liu 1,2,†, Kangli Guo 1,2,†, Nana Zhao 1,2,*, Fu-Jian Xu 1,2,*
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  • ReceivedJul 19, 2019
  • AcceptedAug 6, 2019
  • PublishedAug 30, 2019

Abstract

由多糖和多功能无机纳米颗粒组成的多糖基复合纳米材料在生物医学领域具有潜在的应用价值, 是一种有希望的候选材料. 本文介绍了多糖基复合纳米材料的优良性能及其在成像和治疗中的应用. 除了多糖和无机纳米颗粒这两部分的功能简单结合以外, 复合纳米材料还具有协同性能和功能. 最后, 我们讨论了多糖基复合纳米材料在潜在的临床应用中的挑战和前景.


Funded by

the National Key Research and Development Program of China(2016YFA0201501,2017YFA0106100)

the National Natural Science Foundation of China(51773013,51733001)

and the Fundamental Research Funds for the Central Universities(BHYC1705A,XK1802-2)


Acknowledgment

This work was supported by the National Key Research and Development Program of China (2016YFA0201501 and 2017YFA0106100), the National Natural Science Foundation of China (51773013 and 51733001), and the Fundamental Research Funds for the Central Universities (BHYC1705A and XK1802-2).


Interest statement

The authors declare that they have no conflict of interest.


Contributions statement

Liu Z and Guo K contributed equally to the reference collection and manuscript writing. Zhao N and Xu FJ guided the writing of this paper and contributed to the manuscript revision, figure modification and general discussion.


Author information

Zhiwen Liu received his BSc degree from Shandong University of Technology in 2018. He is currently a master student under the supervision of Prof. Fu-Jian Xu and Prof. Nana Zhao at Beijing University of Chemical Technology. His research interests focus on the development of polysaccharides-based nanohybrids as antibacterial materials.


Kangli Guo received her BSc degree from Beijing Technology and Business University in 2018. She is currently a master student under the supervision of Prof. Fu-Jian Xu and Prof. Nana Zhao at Beijing University of Chemical Technology. Her research interests focus on the synthesis and applications of magnetic nanohybrids.


Nana Zhao received her PhD degree in physical chemistry from Peking University, China in 2008 under the direction of Prof. Limin Qi. After post-doctoral work with Prof. Eugenia Kumacheva at the University of Toronto, Canada and Prof. Lutgard De Jonghe at Lawrence Berkeley National Laboratory, she joined Beijing University of Chemical Technology as an Associate Professor in 2012 and was promoted to Professor in 2016. Her current research interests focus on the design, synthesis and application of versatile organic/inorganic nanohybrids.


Fu-Jian Xu obtained his PhD degree in biomolecular engineering in 2006 from National University of Singapore. He joined Beijing University of Chemical Technology, China as a Professor in 2009. He was recipient of the National Science Foundation for Distinguished Young Scholars (NSFC, 2013) and Cheung Kong Distinguished Professor (Ministry of Education of China, 2014). His research interests focus on functional biomacromolecules.


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  • Figure 1

    Polysaccharides-based nanohybrids composed of flexible polysaccharides and versatile inorganic NPs.

  • Figure 2

    Schematic showing the formation of CS-Au nanohybrids. Reproduced with permission from Ref. [18]. Copyright 2013, Elsevier.

  • Figure 3

    (a) Schematic of DOX-loaded CS-carbon dot nanohybrids for therapeutic application. (b) Schematic of chemotherapy alone or combined photothermal-chemo therapy on cancer cells using nanohybrids as drug carriers. (c, d) In vitro cytotoxicity of 4T1 cells and therapeutic efficacies of nanohybrids for different treatments. Reproduced with permission from Ref. [19]. Copyright 2017, American Chemical Society.

  • Figure 4

    Antibiofilm properties of topical dextran-iron oxide nanohybrids + H2O2 treatments (gray: bacteria, green: nanohybrids, magenta: exopolysaccharides). Reproduced with permission from Ref. [13]. Copyright 2019, American Chemical Society.

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