As a novel kind of biomacromolecular soft material, DNA hydrogel has become one of the hot topics in multidisciplinary researches. Taking advantages of the programmability and abundant functional motifs of DNA based materials, smart DNA hydrogels can be developed with high precision and controllability through reasonable sequence designs and post-modifications. By encoding with different functional DNA structures, such as the molecular-recognition DNA structures and the catalytic DNA structures, smart DNA hydrogel can perform different functions, such as the target-responsive and signal-amplification functions. DNA hydrogels also exhibit good biocompatibility and degradability. Therefore, smart DNA hydrogels hold great promise in biomedical applications, especially in biosensing. In this mini-review, we discuss the different types of smart DNA hydrogels and summarize their biosensing applications. The development prospect of smart DNA hydrogels is also discussed.
国家自然科学基金(21505078,21874076)
中央高校基本科研业务费
天津市自然科学基金(18JCZDJC37800)
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Figure 1
(a) Structure of pH-responsive smart DNA hydrogel
Figure 2
Schematic illustration of photothermal responsive mechanism of smart DNA nanogel
Figure 3
(a) The formation mechanism of photo-responsive smart DNA hydrogel
Figure 4
Schematic illustration of magnetic-responsive smart DNA hydrogel
Figure 5
(a) Logic gate system based on ATP/cocaine responsive smart DNA hydrogel
Figure 6
Schematic illustration of DNA-responsive mechanism of smart DNA hydrogel
Figure 7
(a) Schematic representation of the enzyme-responsive liposome-crosslinked DNA hydrogel
Figure 8
(a) Scheme of the aptamer-crosslinked hydrogel as a colorimetric platform for visual detection
Figure 9
Scheme of DNA hydrogel assembled on the surface of Au electrode for detecting of H2O2
Figure 10
Scheme of DNA hydrogel assembled on the surface of ITO electrode for direct detection of serum samples
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