Smart DNA hydrogels for biosensing applications

Yanhui Bi; Cuiyan Han; Weiwei Guo

doi:10.1360/N032018-00242

SCIENTIA SINICA Chimica

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SCIENTIA SINICA Chimica, Volume 49, Issue 5: 766-775(2019) https://doi.org/10.1360/N032018-00242

Smart DNA hydrogels for biosensing applications

Yanhui Bi^1,†, Cuiyan Han^1,†, Weiwei Guo^1,2,*

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ReceivedNov 3, 2018
AcceptedDec 24, 2018
PublishedFeb 28, 2019

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Abstract

As a novel kind of biomacromolecular soft material, DNA hydrogel has become one of the hot topics in multidisciplinary researches. Taking advantages of the programmability and abundant functional motifs of DNA based materials, smart DNA hydrogels can be developed with high precision and controllability through reasonable sequence designs and post-modifications. By encoding with different functional DNA structures, such as the molecular-recognition DNA structures and the catalytic DNA structures, smart DNA hydrogel can perform different functions, such as the target-responsive and signal-amplification functions. DNA hydrogels also exhibit good biocompatibility and degradability. Therefore, smart DNA hydrogels hold great promise in biomedical applications, especially in biosensing. In this mini-review, we discuss the different types of smart DNA hydrogels and summarize their biosensing applications. The development prospect of smart DNA hydrogels is also discussed.

Funded by

国家自然科学基金(21505078,21874076)

中央高校基本科研业务费

天津市自然科学基金(18JCZDJC37800)

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Figure 1
(a) Structure of pH-responsive smart DNA hydrogel [9]. (b) The mechanism of pH-responsive shape-memory smart DNA hydrogel [17]. (c) Illustration of the preparation process of the K⁺-responsive smart DNA hydrogel ion channel [31] (color online).
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Figure 2
Schematic illustration of photothermal responsive mechanism of smart DNA nanogel [32] (color online).
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Figure 3
(a) The formation mechanism of photo-responsive smart DNA hydrogel [20]. (b) Schematic illustration of photo-responsive shape-memory smart DNA hydrogel [34] (color online).
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Figure 4
Schematic illustration of magnetic-responsive smart DNA hydrogel [38] (color online).
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Figure 5
(a) Logic gate system based on ATP/cocaine responsive smart DNA hydrogel [13]. (b) Schematic illustration of target-responsive smart DNA hydrogel based volumetric bar-chart chip [24]. (c) Working principle of visual detection of Pb²⁺ based on target-responsive hydrogel [45] (color online).
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Figure 6
Schematic illustration of DNA-responsive mechanism of smart DNA hydrogel [46] (color online).
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Figure 7
(a) Schematic representation of the enzyme-responsive liposome-crosslinked DNA hydrogel [25]. (b) Schematic illustration of the double network enzyme-responsive hydrogel [48] (color online).
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Figure 8
(a) Scheme of the aptamer-crosslinked hydrogel as a colorimetric platform for visual detection [49]. (b) Scheme of combination of DNA hydrogel and glucometer [50] (color online).
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Figure 9
Scheme of DNA hydrogel assembled on the surface of Au electrode for detecting of H₂O₂ [52] (color online).
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Figure 10
Scheme of DNA hydrogel assembled on the surface of ITO electrode for direct detection of serum samples [53] (color online).

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Smart DNA hydrogels for biosensing applications

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