SCIENTIA SINICA Informationis, Volume 48, Issue 6: 605-625(2018) https://doi.org/10.1360/N112018-00106

Review of ultra-thin and skin-like solid electronics

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  • ReceivedApr 27, 2018
  • AcceptedMay 7, 2018
  • PublishedJun 13, 2018


Directly integrating the flexible and stretchable electronics with the humanbody has become a developing trend that is promising in healthcare. Skin-like flexible electronics that can seamlessly produce soft and conformalcontact with the human body are of large significance for clinicaldiagnosis, therapy, and human-machine interfacing, as well as for the sensingfunction of robots and so on. Here, we review on the recent progress offlexible and skin-like solid electronics with specific emphasis on theapplication in the long-term and continuous monitoring of basic humanphysical parameters, such as body temperature, surficial strain, bloodoxygen, and blood glucose, as well as energy harvesting. Along with the rapiddevelopment in big data and artificial intelligence, flexible and skin-likesolid electronics are believed to play an important role in human liferesearch and medical applications.


[1] Araki H, Kim J, Zhang S N. Materials and device designs for an epidermal UV colorimetric dosimeter with near field communication capabilities. Adv Funct Mater, 2017, 27: 1604465 CrossRef Google Scholar

[2] Gao W, Emaminejad S, Nyein H Y Y. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 2016, 529: 509-514 CrossRef PubMed ADS Google Scholar

[3] Kim D H, Lu N, Ghaffari R. Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nat Mater, 2011, 10: 316-323 CrossRef PubMed ADS Google Scholar

[4] Kim D H, Viventi J, Amsden J J. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nat Mater, 2010, 9: 511-517 CrossRef PubMed ADS Google Scholar

[5] Lee H, Choi T K, Lee Y B. A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. Nat Nanotech, 2016, 11: 566-572 CrossRef PubMed ADS Google Scholar

[6] Lee J W, Xu R X, Lee S. Soft, thin skin-mounted power management systems and their use in wireless thermography. Proc Natl Acad Sci USA, 2016, 113: 6131-6136 CrossRef PubMed ADS Google Scholar

[7] Lu B W, Chen Y, Ou D P. Ultra-flexible piezoelectric devices integrated with heart to harvest the biomechanical energy. Sci Rep, 2015, 5: 16065 CrossRef PubMed ADS Google Scholar

[8] Son D, Lee J, Qiao S T. Multifunctional wearable devices for diagnosis and therapy of movement disorders. Nat Nanotech, 2014, 9: 397-404 CrossRef PubMed ADS Google Scholar

[9] Smith D J. Clinopyroxene precursors to amphibole sponge in arc crust. Nat Commun, 2014, 5: 4329 CrossRef PubMed ADS Google Scholar

[10] Xu L Z, Gutbrod S R, Ma Y J. Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy. Adv Mater, 2015, 27: 1731-1737 CrossRef PubMed Google Scholar

[11] Hammock M L, Chortos A, Tee B C K. 25th anniversary article: the evolution of electronic skin (e-skin): a brief history, design considerations, and recent progress. Adv Mater, 2013, 25: 5997-6038 CrossRef PubMed Google Scholar

[12] Hwang S W, Tao H, Kim D H. A physically transient form of silicon electronics. Science, 2012, 337: 1640-1644 CrossRef PubMed ADS Google Scholar

[13] Kim B H, Kim J H, Persano L. Dry transient electronic systems by use of materials that sublime. Adv Funct Mater, 2017, 27: 1606008 CrossRef Google Scholar

[14] Lee G, Kang S K, Won S M. Fully biodegradable microsupercapacitor for power storage in transient electronics. Adv Energy Mater, 2017, 7: 1700157 CrossRef Google Scholar

[15] Yu K J, Kuzum D, Hwang S W. Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. Nat Mater, 2016, 15: 782-791 CrossRef PubMed ADS Google Scholar

[16] Park C W, Kang S K, Hernandez H L. Thermally triggered degradation of transient electronic devices. Adv Mater, 2015, 27: 3783-3788 CrossRef PubMed Google Scholar

[17] Chen Y, Lu B W, Ou D P. Mechanics of flexible and stretchable piezoelectrics for energy harvesting. Sci China-Phys Mech Astron, 2015, 58: 594601 CrossRef ADS Google Scholar

[18] Dagdeviren C, Yang B D, Su Y. Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm. Proc Natl Acad Sci USA, 2014, 111: 1927-1932 CrossRef PubMed ADS Google Scholar

[19] Choi M K, Yang J, Kang K. Wearable red-green-blue quantum dot light-emitting diode array using high-resolution intaglio transfer printing. Nat Commun, 2015, 6: 7149 CrossRef PubMed ADS Google Scholar

[20] Kim J, Lee J, Son D. Deformable devices with integrated functional nanomaterials for wearable electronics. Nano Convergence, 2016, 3: 4 CrossRef PubMed ADS Google Scholar

[21] Feng X, Lu B W, Wu J, et al. Review on stretchable and fexible inorganic electronics. Acta Phys Sin, 2014, 63: 014201. Google Scholar

[22] Choi S, Lee H, Ghaffari R. Recent advances in flexible and stretchable bio-electronic devices integrated with nanomaterials. Adv Mater, 2016, 28: 4203-4218 CrossRef PubMed Google Scholar

[23] Choi C, Choi M K, Hyeon T. Nanomaterial-based soft electronics for healthcare applications. ChemNanoMat, 2016, 2: 1006-1017 CrossRef Google Scholar

[24] Wang G J N, Gasperini A, Bao Z N. Stretchable polymer semiconductors for plastic electronics. Adv Electron Mater, 2018, 4: 1700429 CrossRef Google Scholar

[25] Schweicher G, Lemaur V, Niebel C. Bulky end-capped [1]benzothieno[3,2-b]benzothiophenes: reaching high-mobility organic semiconductors by fine tuning of the crystalline solid-state order. Adv Mater, 2015, 27: 3066-3072 CrossRef PubMed Google Scholar

[26] Xu J, Wang S H, Wang G J N. Highly stretchable polymer semiconductor films through the nanoconfinement effect. Science, 2017, 355: 59-64 CrossRef PubMed ADS Google Scholar

[27] Wang S H, Xu J, Wang W C. Skin electronics from scalable fabrication of an intrinsically stretchable transistor array. Nature, 2018, 555: 83-88 CrossRef PubMed ADS Google Scholar

[28] Oh J Y, Rondeau-Gagné S, Chiu Y C. Intrinsically stretchable and healable semiconducting polymer for organic transistors. Nature, 2016, 539: 411-415 CrossRef PubMed ADS Google Scholar

[29] Gu X D, Shaw L, Gu K. The meniscus-guided deposition of semiconducting polymers. Nat Commun, 2018, 9: 534 CrossRef PubMed ADS Google Scholar

[30] Giri G, DeLongchamp D M, Reinspach J. Effect of solution shearing method on packing and disorder of organic semiconductor polymers. Chem Mater, 2015, 27: 2350-2359 CrossRef Google Scholar

[31] Worfolk B J, Andrews S C, Park S. Ultrahigh electrical conductivity in solution-sheared polymeric transparent films. Proc Natl Acad Sci USA, 2015, 112: 14138-14143 CrossRef PubMed ADS Google Scholar

[32] Kim D H, Lu N S, Huang Y G. Materials for stretchable electronics in bioinspired and biointegrated devices. MRS Bull, 2012, 37: 226-235 CrossRef Google Scholar

[33] Kim D H, Lu N, Ma R. Epidermal electronics. Science, 2011, 333: 838-843 CrossRef PubMed ADS Google Scholar

[34] Meitl M A, Zhu Z T, Kumar V. Transfer printing by kinetic control of adhesion to an elastomeric stamp. Nat Mater, 2006, 5: 33-38 CrossRef ADS Google Scholar

[35] Song Y M, Xie Y, Malyarchuk V. Digital cameras with designs inspired by the arthropod eye. Nature, 2013, 497: 95-99 CrossRef PubMed ADS Google Scholar

[36] Zhu C X, Chortos A, Wang Y. Stretchable temperature-sensing circuits with strain suppression based on carbon nanotube transistors. Nat Electron, 2018, 1: 183-190 CrossRef Google Scholar

[37] Webb R C, Bonifas A P, Behnaz A. Ultrathin conformal devices for precise and continuous thermal characterization of human skin. Nat Mater, 2013, 12: 938-944 CrossRef PubMed ADS Google Scholar

[38] Tien N T, Jeon S, Kim D I. A flexible bimodal sensor array for simultaneous sensing of pressure and temperature. Adv Mater, 2014, 26: 796-804 CrossRef PubMed Google Scholar

[39] Stücker M, Struk A, Altmeyer P. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. J Physiol, 2002, 538: 985-994 CrossRef Google Scholar

[40] Chen Y, Lu B W, Chen Y H. Breathable and stretchable temperature sensors inspired by skin. Sci Rep, 2015, 5: 11505 CrossRef PubMed ADS Google Scholar

[41] Zhang Y H, Webb R C, Luo H Y. Theoretical and experimental studies of epidermal heat flux sensors for measurements of core body temperature. Adv Healthc Mater, 2016, 5: 119-127 CrossRef PubMed Google Scholar

[42] Webb R C, Ma Y J, Krishnan S. Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow. Sci Adv, 2015, 1: 1500701 CrossRef PubMed ADS Google Scholar

[43] Webb R C, Pielak R M, Bastien P. Thermal transport characteristics of human skin measured in vivo using ultrathin conformal arrays of thermal sensors and actuators. PLoS ONE, 2015, 10: 0118131 CrossRef PubMed ADS Google Scholar

[44] Xu F, Durham Iii J W, Wiley B J. Strain-release assembly of nanowires on stretchable substrates. ACS Nano, 2011, 5: 1556-1563 CrossRef PubMed Google Scholar

[45] Wang Y, Yang R, Shi Z W. Super-elastic graphene ripples for flexible strain sensors. ACS Nano, 2011, 5: 3645-3650 CrossRef PubMed Google Scholar

[46] Pan L J, Chortos A, Yu G H. An ultra-sensitive resistive pressure sensor based on hollow-sphere microstructure induced elasticity in conducting polymer film. Nat Commun, 2014, 5: 3002 CrossRef PubMed ADS Google Scholar

[47] Kim Y, Kim Y, Lee C. Thin polysilicon gauge for strain measurement of structural elements. IEEE Sensor J, 2010, 10: 1320-1327 CrossRef Google Scholar

[48] Chen Y H, Lu B W, Chen Y. Biocompatible and ultra-flexible inorganic strain sensors attached to skin for long-term vital signs monitoring. IEEE Electron Device Lett, 2016, 37: 496-499 CrossRef ADS Google Scholar

[49] Chen Y G, Lu B W, Chen Y, et al. Ultra-thin and ultra-flexible temperature/strain sensor with CNT nanostrips. In: Proceedings of IEEE International Conference on Electron Devices and Solid-State Circuits (EDSSC), Hong Kong, 2016. Google Scholar

[50] Miller S, Bao Z. Fabrication of flexible pressure sensors with microstructured polydimethylsiloxane dielectrics using the breath figures method. J Mater Res, 2015, 30: 3584-3594 CrossRef ADS Google Scholar

[51] Tee B C K, Chortos A, Dunn R R. Tunable flexible pressure sensors using microstructured elastomer geometries for intuitive electronics. Adv Funct Mater, 2014, 24: 5427-5434 CrossRef Google Scholar

[52] Park S, Kim H, Vosgueritchian M. Stretchable energy-harvesting tactile electronic skin capable of differentiating multiple mechanical stimuli modes. Adv Mater, 2014, 26: 7324-7332 CrossRef PubMed Google Scholar

[53] Pang C, Koo J H, Nguyen A. Highly skin-conformal microhairy sensor for pulse signal amplification. Adv Mater, 2015, 27: 634-640 CrossRef PubMed Google Scholar

[54] Shervedani R K, Mehrjardi A H, Zamiri N. A novel method for glucose determination based on electrochemical impedance spectroscopy using glucose oxidase self-assembled biosensor. Bioelectrochemistry, 2006, 69: 201-208 CrossRef PubMed Google Scholar

[55] Yang X, Zhang A Y, Wheeler D A. Direct molecule-specific glucose detection by Raman spectroscopy based on photonic crystal fiber. Anal Bioanal Chem, 2012, 402: 687-691 CrossRef PubMed Google Scholar

[56] Cho O K, Kim Y O, Mitsumaki H. Noninvasive measurement of glucose by metabolic heat conformation method. Clinical Chem, 2004, 50: 1894-1898 CrossRef Google Scholar

[57] Shibata H, Heo Y J, Okitsu T. Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring. Proc Natl Acad Sci USA, 2010, 107: 17894-17898 CrossRef PubMed ADS Google Scholar

[58] Larin K V, Eledrisi M S, Motamedi M. Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects. Diabetes Care, 2002, 25: 2263-2267 CrossRef Google Scholar

[59] Ghosn M G, Sudheendran N, Wendt M. Monitoring of glucose permeability in monkey skin in vivo using optical coherence tomography. J Biophoton, 2009, 3: 25-33 CrossRef PubMed Google Scholar

[60] Tura A, Maran A, Pacini G. Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diabetes Res Clin Pract, 2007, 77: 16-40 CrossRef PubMed Google Scholar

[61] Vashist S K. Non-invasive glucose monitoring technology in diabetes management: a review. Anal Chim Acta, 2012, 750: 16-27 CrossRef PubMed Google Scholar

[62] Chen Y H, Lu S Y, Feng X. Skin-like nanostrucutred biosensor system for noninvasive blood glucose monitoring. In: Proceedings of IEEE International Electron Devices Meeting, San Francisco, 2017. Google Scholar

[63] Chen Y H, Lu S Y, Zhang S S. Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring. Sci Adv, 2017, 3: 1701629 CrossRef PubMed ADS Google Scholar

[64] Li H C, Xu Y, Li X M. Epidermal inorganic optoelectronics for blood oxygen measurement. Adv Healthc Mater, 2017, 6: 1601013 CrossRef PubMed Google Scholar

[65] Jegadeesan R, Guo Y X. Topology selection and efficiency improvement of inductive power links. IEEE Trans Antenn Propag, 2012, 60: 4846-4854 CrossRef ADS Google Scholar

[66] Jegadeesan R, Guo Y X. A study on the inductive power links for implantable biomedical devices. In: Proceedings of IEEE Antennas and Propagation Society International Symposium (APSURSI), Toronto, 2010. Google Scholar

[67] Harrison R R. Designing efficient inductive power links for implantable devices. In: Proceedings of IEEE International Symposium on Circuits and Systems, New Orleans, 2007. Google Scholar

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