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SCIENTIA SINICA Vitae, Volume 49, Issue 9: 1069-1075(2019) https://doi.org/10.1360/SSV-2019-0153

Molecular mechanisms of infection site recognition by enteric pathogens

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  • ReceivedJul 30, 2019
  • AcceptedAug 12, 2019
  • PublishedSep 16, 2019

Abstract

In humans, the bacterial pathogen infections occur primarily in the intestine. Every year, intestinal diseases cause 1.5–2.5 million deaths, holding the third highest mortality rate among all diseases. Different enteric pathogens recognize different intestinal sites for colonization and infection, among which human small intestine and large intestine are the main infection sites. During the pathogenic process, enteric pathogens sense a series of intestinal signals to accurately identify their infection sites, and adhere to or invade the intestinal epithelium through activating the expression of virulence genes. Here, we review the molecular mechanisms by which two representative enteric pathogens (large intestinal pathogen enterohemorrhagic Escherichia coli and small intestinal pathogen Salmonella typhimurium) recognize their infection sites.


Funded by

国家自然科学基金(31530083,31800125,31800126)

天津市自然科学基金(17JCQNJC09300)


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