SCIENTIA SINICA Vitae, Volume 49, Issue 9: 1100-1108(2019) https://doi.org/10.1360/SSV-2019-0156

The cell source in tissue regeneration of vascular grafts

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  • ReceivedJul 23, 2019
  • AcceptedAug 9, 2019
  • PublishedSep 17, 2019


The development of small-diameter artificial vascular grafts has become a research hotspot in recent years. To achieve long-term patency, an ideal vascular graft should have the capacity to recruit host cells to participate in vascular tissue regeneration. Based on previous research, we provide detailed descriptions of the cell sources and cell types involved in vascular graft regeneration. Methodology to determine host cell infiltration and the limitations of current techniques are also discussed.

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  • Figure 1

    Schematic diagram of Y chromosome distribution in composite vascular grafts[6]

  • Figure 2

    Schematic diagram of a composite vascular graft[9]

  • Figure 3

    Illustration of the bi-layered PCL vascular graft[18]

  • Figure 4

    Illustration of macrophages involved in vascular graft regeneration[24]

  • Figure 5

    Schematic diagram of vascular regeneration of hBMC-seeded biodegradable scaffolds[25]

  • Figure 6

    Schematic of tissue regeneration in thick-fiber and thin-fiber PCL vascular grafts[24]

  • Figure 7

    Dkk3 increases Sca-1+ adventitia stem cell infiltration[15]. A: Schematic illustration of 3 types of PCL grafts. B: Representative immunofluorescence images of Sca-1+ cells. C: Quantification of Sca-1+ cells infiltration into vascular wall

  • Table 1   Cell sources, cell types, migration patterns and contribution rates involved in vascular tissue regeneration




















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