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SCIENTIA SINICA Vitae, Volume 49, Issue 9: 1045-1053(2019) https://doi.org/10.1360/SSV-2019-0158

Mechanism of mitophagy in cell homeostasis

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  • ReceivedJul 25, 2019
  • AcceptedAug 7, 2019
  • PublishedSep 9, 2019

Abstract

Mitophagy is an evolutionally conserved mechanism to remove dysfunctional or unwanted mitochondria, thus orchestrates mitochondrial number and cell metabolism. So its molecular mechanism is a hot topic in mitochondrial fields. This review summarizes the current progress in the molecular mechanism of mitochondria, and discusses the related some regulatory mechanism. We review the molecular mechanism and contributions of mitophagy in physiological and pathological contexts and discuss emerging findings, highlighting the potential value of mitophagy regulation. We also hope related mitophagy molecular pathways might be exploited for the mitochondrial function.


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