GMP-quadruplex-based hydrogels stabilized by lanthanide ions

Jin Zhang; Xiaoyang Li; Xiuping Sun; Aixin Song; Yebang Tan; Jingcheng Hao

doi:10.1007/s11426-017-9187-x

SCIENCE CHINA Chemistry

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SCIENCE CHINA Chemistry, Volume 61 , Issue 5 : 604-612(2018) https://doi.org/10.1007/s11426-017-9187-x

GMP-quadruplex-based hydrogels stabilized by lanthanide ions

Jin Zhang , Xiaoyang Li , Xiuping Sun , Aixin Song ^*, Yebang Tan , Jingcheng Hao

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AcceptedDec 4, 2017
PublishedFeb 12, 2018

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Abstract

Funded by

the National Natural Science Foundation of China(21573134,21420102006)

hydrogel

G-quadruplex

ion-dipole interaction

electrostatic interaction

fluorescence enhancement

hydrogen bonding

Acknowledgment

This work was supported by the National Natural Science Foundation of China (21573134, 21420102006).

Interest statement

The authors declare that they have no conflict of interest.

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Scheme 1
The proposed formation mechanism of G-quadruplex and the coordination polymer nanoparticles at different pH (color online).
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Figure 1
Photographs of G-hydrogel samples formed by 50 mM GMP/4 mM La(NO₃)₃ at different pH.
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Figure 2
TEM images of hydrogels formed by 50 mM GMP with 4 mM lanthanide ions at pH 3. (a, b) La(NO₃)₃; (c, d) Ce(NO₃)₃; (e, f) Eu(NO₃)₃; (g, h) Tb(NO₃)₃.
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Figure 3
The stress sweep results of hydrogels formed by 50 mM GMP with (a) 4 mM La(NO₃)₃ at different pH and (b) different concentrations of La(NO₃)₃ at pH 3.
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Figure 4
The stress sweep results of hydrogels formed by 50 mM GMP with (a) 4 mM Ln(NO₃)₃ and (b) different concentrations of monovalent cations at pH 3.
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Figure 5
(a) FT-IR spectra of GMP and hydrogels formed by 50 mM GMP with 4 mM lanthanide ions; (b) the model of G-quartet.
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Figure 6
(a) Small and (b) wide angle XRD patterns of GMP and hydrogels formed by 50 mM GMP with 4 mM lanthanide ions at pH 3.
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Figure 7
CD spectra of (a) 50 mM GMP and hydrogels of 50 mM GMP/3 mM Ln³⁺ at pH 3 and (b) hydrogels of 50 mM GMP/2 mM La³⁺ at different pH (color online).
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Figure 8
The protonation and deprotonation equilibrium of GMP.
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Figure 9
TEM images of (a) nanoparticles formed by 50 mM GMP/4 mM La³⁺ at pH 7.8 and (b) hydrogel formed by 50 mM GMP/4 mM La³⁺ at pH 3.
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Figure 10
(a) The photos of GMP hydrogel without ThT, GMP solution and hydrogels induced by lanthanide ions (La³⁺, Ce³⁺, Eu³⁺ and Tb³⁺) with 100 µM ThT under the irradiation at 365 nm; (b, c) the fluorescence spectra of (b) different solutions and Eu³⁺/GMP hydrogel and (c) hydrogels induced by different lanthanide ions.
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Figure 11
Fluorescence spectra of hydrogels formed by (a) 50 mM GMP/12 mM La(NO₃)₃ at different pH and (b) 50 mM GMP with different concentrations of La(NO₃)₃ at pH 3.