a. CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
b. Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China
c. University of Chinese Academy of Sciences, Beijing, China
Corresponding author emails: (
Coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), are highly transmissible pathogens, and they can be lethal in humans. Bats are believed to be the original sources of these lethal pathogens. In December 2019, a cluster of pneumonia cases was reported in Wuhan and a novel coronavirus (2019-nCoV) has been linked to the causative agent. Early studies indicated that the new virus was genetically similar to a bat betacoronavirus, providing evidence for bat origin of the third human-infecting coronavirus in less than 20 years. We here highlight the potential for viral spillover from animals to humans and discuss evolutionary mechanisms leading to the outbreaks.
Copyright 2020 CHINA SCIENCE PUBLISHING & MEDIA LTD. 中国科技出版传媒股份有限公司 版权所有