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SCIENTIA SINICA Chimica
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SCIENTIA SINICA Chimica, Volume 49 , Issue 5 : 787-800(2019) https://doi.org/10.1360/N032018-00199

Recent advances of single molecule/particle imaging with optical microscopic methods

Zhongju Ye , Hua Liu , Lehui Xiao *
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  • ReceivedAug 27, 2018
  • AcceptedSep 13, 2018
  • PublishedOct 30, 2018
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Abstract

Single-molecule and -particle imaging with optical microscopic methods have been widely used in various fields with the advantages of high resolution, high throughput and excellent sensitivity. This review summarized recent progresses of optical microscopic imaging of single-molecule and -particle in the areas of molecular detection, super-resolution imaging and single-particle catalysis. At last, we outlined the challenges and prospect of optical microscopic imaging techniques for single-molecule and -particle assay in biomedical applications.


Funded by

国家自然科学基金(21522502)


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    Figure 1

    Schematic diagram of single-molecule detection. (A) Schematic illustration of biomarker detection using scattering-based single particle intensity measurement with a dark-field microscope [44]. (B) Schematic diagram of the light path for the optical microscopic imaging of single nanoparticle and the principle of the color-coded SPD for PPi assay [45]. (C) Schematic diagram of the light path for the optical microscopic imaging of UCNPs and the principle of digital immunosorbent assay by single-particle enumeration [50]. (D) Detection of adenosine molecules based on the single molecule photobleaching measurement [51]. (E) Telomerase detection by single molecule stochastic binding of the telomeric repeats, single-molecule fluorescent trajectories in the presence and absence of telomerase [52] (color online).

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    Figure 2

    Single-particle tracking. (A) Schematic representation of the diverse lateral diffusion of molecular components on the cell surface [57]. (B) Schematic diagram of TAT-modified GNPs diffusion on lipid membrane [61]. (C) Dual-view optics for single particle translational and rotational tracking [69]. (D) Influenza viruses moving along different configurations of microtubules [71] (color online).

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    Figure 3

    (A) Super-resolution imaging permits the nature and morphology of intracellular Aβ1-42 aggregates to be probed in situ [82]. (B) Super-resolution imaging and analysis of cell-surface glycoproteins [88]. (C) A sequence of fluorescence microscopy images showing the blinking behavior of an E. coli labeled with 20% PCBM-doped PFBT CPNs [89]. (D) Super-resolution imaging of single molecules in a conjugated hotspot region [90] (color online).

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    Figure 4

    Single-particle catalysis and super-resolution imaging. (A) Single-turnover detection of single-Au-nanoparticle catalysis [102]. (B) Autocorrelation functions of the τoff (a) and τon (b) from the turnover trajectory of a single 9.1 nm Au-nanoparticle; dependence of the activity fluctuation rate of the τoff reaction (c) and the τon reaction (d) [96]. (C) Quantitative reaction kinetics of a single Au@mSiO2 nanorod at subparticle resolution [106]. (D) Spatially resolved activity quantitation on single Au@mSiO2 nanoplates [107] (color online).