References

[1] Hamada N, Sato T. Cataractogenesis following high-LET radiation exposure. Mutat Res, 2016, 770: 262–291. Google Scholar http://scholar.google.com/scholar_lookup?title=Hamada N, Sato T. Cataractogenesis following high-LET radiation exposure. Mutat Res, 2016, 770: 262–291&

[2] Rudobeck E, Bellone J A, Szücs A, et al. Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease—Implications for space travel. PLoS One, 2017, 12: e0186168. Google Scholar http://scholar.google.com/scholar_lookup?title=Rudobeck E, Bellone J A, Szücs A, et al. Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease—Implications for space travel. PLoS One, 2017, 12: e0186168&

[3] Cucinotta F A, To K, Cacao E. Predictions of space radiation fatality risk for exploration missions. Life Sci Space Res, 2017, 13: 1–11. Google Scholar http://scholar.google.com/scholar_lookup?title=Cucinotta F A, To K, Cacao E. Predictions of space radiation fatality risk for exploration missions. Life Sci Space Res, 2017, 13: 1–11&

[4] Barcellos-Hoff M H, Blakely E A, Burma S, et al. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res, 2015, 6: 92–103. Google Scholar http://scholar.google.com/scholar_lookup?title=Barcellos-Hoff M H, Blakely E A, Burma S, et al. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res, 2015, 6: 92–103&

[5] Coleman M A, Sasi S P, Onufrak J, et al. Low-dose radiation affects cardiac physiology: Gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol, 2015, 309: 1947−1963. Google Scholar http://scholar.google.com/scholar_lookup?title=Coleman M A, Sasi S P, Onufrak J, et al. Low-dose radiation affects cardiac physiology: Gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol, 2015, 309: 1947−1963&

[6] Zhao L, Mi D, Sun Y Q. Issues and challenges of space radiation risk assessment in manned deep space exploration missions (in Chinese). Chin Sci Bull, 2018, 63: 1523-1537 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Issues and challenges of space radiation risk assessment in manned deep space exploration missions (in Chinese)&author=Zhao L&author=Mi D&author=Sun Y Q&publication_year=2018&journal=Chin Sci Bull&volume=63&pages=1523-1537

[7] Zhao L, Shang Y X, Yuan S, et al. Research progress of space radiation protection technologies in manned deep space exploration missions (in Chinese). Chin Sci Bull, 2019, 64: 2087-2103 CrossRef Google Scholar http://scholar.google.com/scholar_lookup?title=Research progress of space radiation protection technologies in manned deep space exploration missions (in Chinese)&author=Zhao L&author=Shang Y X&author=Yuan S&publication_year=2019&journal=Chin Sci Bull&volume=64&pages=2087-2103

[8] Bláha P, Koshlan N A, Koshlan I V, et al. Delayed effects of accelerated heavy ions on the induction of HPRT mutations in V79 hamster cells. Mutat Res, 2017, 803-805: 35–41. Google Scholar http://scholar.google.com/scholar_lookup?title=Bláha P, Koshlan N A, Koshlan I V, et al. Delayed effects of accelerated heavy ions on the induction of HPRT mutations in V79 hamster cells. Mutat Res, 2017, 803-805: 35–41&

[9] Lu T, Zhang Y, Wong M, et al. Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station. Life Sci Space Res, 2017, 12: 24–31. Google Scholar http://scholar.google.com/scholar_lookup?title=Lu T, Zhang Y, Wong M, et al. Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station. Life Sci Space Res, 2017, 12: 24–31&

[10] Lu T, Zhang Y, Kidane Y, et al. Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space. PLoS One, 2017, 12: e0170358 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space&author=Lu T&author=Zhang Y&author=Kidane Y&publication_year=2017&journal=PLoS One&volume=12&pages=e0170358

[11] Kadhim M, Salomaa S, Wright E, et al. Non-targeted effects of ionising radiation—Implications for low dose risk. Mutat Res, 2013, 752: 84–98. Google Scholar http://scholar.google.com/scholar_lookup?title=Kadhim M, Salomaa S, Wright E, et al. Non-targeted effects of ionising radiation—Implications for low dose risk. Mutat Res, 2013, 752: 84–98&

[12] Moreno-Villanueva M, Wong M, Lu T, et al. Interplay of space radiation and microgravity in DNA damage and DNA damage response. NPJ Microgravity, 2017, 3: 14. Google Scholar http://scholar.google.com/scholar_lookup?title=Moreno-Villanueva M, Wong M, Lu T, et al. Interplay of space radiation and microgravity in DNA damage and DNA damage response. NPJ Microgravity, 2017, 3: 14&

[13] George K, Rhone J, Beitman A, et al. Cytogenetic damage in the blood lymphocytes of astronauts: Effects of repeat long-duration space missions. Mutat Res, 2013, 756: 165–169. Google Scholar http://scholar.google.com/scholar_lookup?title=George K, Rhone J, Beitman A, et al. Cytogenetic damage in the blood lymphocytes of astronauts: Effects of repeat long-duration space missions. Mutat Res, 2013, 756: 165–169&

[14] Snijders A M, Mannion B J, Leung S G, et al. Micronucleus formation in human keratinocytes is dependent on radiation quality and tissue architecture. Environ Mol Mutagen, 2015, 56: 22–31. Google Scholar http://scholar.google.com/scholar_lookup?title=Snijders A M, Mannion B J, Leung S G, et al. Micronucleus formation in human keratinocytes is dependent on radiation quality and tissue architecture. Environ Mol Mutagen, 2015, 56: 22–31&

[15] Chen W R, Feng Y J, Liu J G, et al. Effects of space radiation on micronucleus of lymphocyte, peroxided lipid of serum and antioxidant activity in astronauts (in Chinese). Chin Sci Bull (Chin Ver), 2001, 20: 1676−1682 [陈蔚如, 冯英进, 刘绛光, 等. 宇宙辐射对飞行人员淋巴细胞微核及血清过氧化脂质和抗氧化活性的影响. 科学通报, 2001, 20: 1676−1682]. Google Scholar http://scholar.google.com/scholar_lookup?title=Chen W R, Feng Y J, Liu J G, et al. Effects of space radiation on micronucleus of lymphocyte, peroxided lipid of serum and antioxidant activity in astronauts (in Chinese). Chin Sci Bull (Chin Ver), 2001, 20: 1676−1682 [陈蔚如, 冯英进, 刘绛光, 等. 宇宙辐射对飞行人员淋巴细胞微核及血清过氧化脂质和抗氧化活性的影响. 科学通报, 2001, 20: 1676−1682]&

[16] Turker M S, Grygoryev D, Lasarev M, et al. Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change. PLoS One, 2017, 12: e0180412. Google Scholar http://scholar.google.com/scholar_lookup?title=Turker M S, Grygoryev D, Lasarev M, et al. Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change. PLoS One, 2017, 12: e0180412&

[17] Battista N, Meloni M A, Bari M, et al. 5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: Data from the ROALD experiment. FASEB J Off Publ Fed Am Soc Exp Biol, 2012, 26: 1791–1798. Google Scholar http://scholar.google.com/scholar_lookup?title=Battista N, Meloni M A, Bari M, et al. 5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: Data from the ROALD experiment. FASEB J Off Publ Fed Am Soc Exp Biol, 2012, 26: 1791–1798&

[18] Gan L, Wang Z, Si J, et al. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion ⁵⁶Fe radiation induced brain injury in mice. Toxicol Appl Pharmacol, 2018, 341: 1–7. Google Scholar http://scholar.google.com/scholar_lookup?title=Gan L, Wang Z, Si J, et al. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion ⁵⁶Fe radiation induced brain injury in mice. Toxicol Appl Pharmacol, 2018, 341: 1–7&

[19] Zhao B L. Antioxidation of tea polyphenols (in Chinese). Chin Sci Bull (Chin Ver), 2002, 16: 1206−1210 [赵保路. 茶多酚的抗氧化作用. 科学通报, 2002, 16: 1206−1210]. Google Scholar http://scholar.google.com/scholar_lookup?title=Zhao B L. Antioxidation of tea polyphenols (in Chinese). Chin Sci Bull (Chin Ver), 2002, 16: 1206−1210 [赵保路. 茶多酚的抗氧化作用. 科学通报, 2002, 16: 1206−1210]&

[20] Li W, Ge C, Yang L, et al. CBLB502, an agonist of toll-like receptor 5, has antioxidant and scavenging free radicals activities in vitro. Int J Biol Macromol, 2016, 82: 97-103 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=CBLB502, an agonist of toll-like receptor 5, has antioxidant and scavenging free radicals activities in vitro&author=Li W&author=Ge C&author=Yang L&publication_year=2016&journal=Int J Biol Macromol&volume=82&pages=97-103

[21] Burns F J, Tang M, Frenkel K, et al. Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiat Environ Biophys, 2007, 46: 195–199. Google Scholar http://scholar.google.com/scholar_lookup?title=Burns F J, Tang M, Frenkel K, et al. Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiat Environ Biophys, 2007, 46: 195–199&

[22] Kim H J, Ha J H, Kim S W, et al. Effects of combined treatment of sodium hypochlorite/ionizing radiation and addition of vitamin B(1) on microbial flora of oyster and short-necked clam. Foodborne Pathog Dis, 2011, 8: 825–830. Google Scholar http://scholar.google.com/scholar_lookup?title=Kim H J, Ha J H, Kim S W, et al. Effects of combined treatment of sodium hypochlorite/ionizing radiation and addition of vitamin B(1) on microbial flora of oyster and short-necked clam. Foodborne Pathog Dis, 2011, 8: 825–830&

[23] Kennedy A R, Zhou Z, Donahue J J, et al. Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants. Radiat Res, 2006, 166: 327–332. Google Scholar http://scholar.google.com/scholar_lookup?title=Kennedy A R, Zhou Z, Donahue J J, et al. Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants. Radiat Res, 2006, 166: 327–332&

[24] Kong F Q, Wang X, Ni M N, et al. Effects of DNA concentration on radiation-induced DNA damage (in Chinese). Chin Sci Bull (Chin Ver), 2007, 24: 2826−2831 [孔福全, 王潇, 倪嵋楠, 等. 辐射致DNA损伤中DNA浓度的影响. 科学通报, 2007, 24: 2826−2831]. Google Scholar http://scholar.google.com/scholar_lookup?title=Kong F Q, Wang X, Ni M N, et al. Effects of DNA concentration on radiation-induced DNA damage (in Chinese). Chin Sci Bull (Chin Ver), 2007, 24: 2826−2831 [孔福全, 王潇, 倪嵋楠, 等. 辐射致DNA损伤中DNA浓度的影响. 科学通报, 2007, 24: 2826−2831]&

[25] Lulli M, Witort E, Papucci L, et al. Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo. J Radiat Res, 2012, 53: 695–703. Google Scholar http://scholar.google.com/scholar_lookup?title=Lulli M, Witort E, Papucci L, et al. Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo. J Radiat Res, 2012, 53: 695–703&

[26] Hosseinimehr S J. The protective effects of trace elements against side effects induced by ionizing radiation. Radiat Oncol J, 2015, 33: 66–74. Google Scholar http://scholar.google.com/scholar_lookup?title=Hosseinimehr S J. The protective effects of trace elements against side effects induced by ionizing radiation. Radiat Oncol J, 2015, 33: 66–74&

[27] Li X M, Tan Y, Huang C Q, et al. MMP inhibitor ilomastat improves survival of mice exposed to γ-irradiation. Biomed Environ Sci, 2018, 31: 467–472. Google Scholar http://scholar.google.com/scholar_lookup?title=Li X M, Tan Y, Huang C Q, et al. MMP inhibitor ilomastat improves survival of mice exposed to γ-irradiation. Biomed Environ Sci, 2018, 31: 467–472&

[28] Clemente A, Sonnante G, Domoney C. Bowman-Birk inhibitors from legumes and human gastrointestinal health: Current status and perspectives. Curr Protein Pept Sci, 2011, 12: 358–373. Google Scholar http://scholar.google.com/scholar_lookup?title=Clemente A, Sonnante G, Domoney C. Bowman-Birk inhibitors from legumes and human gastrointestinal health: Current status and perspectives. Curr Protein Pept Sci, 2011, 12: 358–373&

[29] Kleiman N J, Stewart F A, Hall E J. Modifiers of radiation effects in the eye. Life Sci Space Res, 2017, 15: 43–54. Google Scholar http://scholar.google.com/scholar_lookup?title=Kleiman N J, Stewart F A, Hall E J. Modifiers of radiation effects in the eye. Life Sci Space Res, 2017, 15: 43–54&

[30] Barrett T, Wilhite S E, Ledoux P, et al. NCBI GEO: Archive for functional genomics data sets—Update. Nucleic Acids Res, 2013, 41: D991-D995 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=NCBI GEO: Archive for functional genomics data sets—Update&author=Barrett T&author=Wilhite S E&author=Ledoux P&publication_year=2013&journal=Nucleic Acids Res&volume=41&pages=D991-D995

[31] Fabregat A, Jupe S, Matthews L, et al. The reactome pathway knowledgebase. Nucleic Acids Res, 2018, 46: D649–D655. Google Scholar http://scholar.google.com/scholar_lookup?title=Fabregat A, Jupe S, Matthews L, et al. The reactome pathway knowledgebase. Nucleic Acids Res, 2018, 46: D649–D655&

[32] Keshava Prasad T S, Goel R, Kandasamy K, et al. Human protein reference database—2009 update. Nucleic Acids Res, 2009, 37: D767−D772. Google Scholar http://scholar.google.com/scholar_lookup?title=Keshava Prasad T S, Goel R, Kandasamy K, et al. Human protein reference database—2009 update. Nucleic Acids Res, 2009, 37: D767−D772&

[33] The Gene Ontology Consortium. The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res, 2019, 47: D330–D338. Google Scholar http://scholar.google.com/scholar_lookup?title=The Gene Ontology Consortium. The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res, 2019, 47: D330–D338&

[34] Kanehisa M, Sato Y, Furumichi M, et al. New approach for understanding genome variations in KEGG. Nucleic Acids Res, 2019, 47: D590–D595. Google Scholar http://scholar.google.com/scholar_lookup?title=Kanehisa M, Sato Y, Furumichi M, et al. New approach for understanding genome variations in KEGG. Nucleic Acids Res, 2019, 47: D590–D595&

[35] Xia J W, Zhan W L, Wei B W, et al. Heavy ions research facility in Lanzhou (HIRFL) (in Chinese). Chin Sci Bull, 2016, 4: 467−477 [夏佳文, 詹文龙, 魏宝文, 等. 兰州重离子加速器研究装置HIRFL. 科学通报 2016, 4: 467−477]. Google Scholar http://scholar.google.com/scholar_lookup?title=Xia J W, Zhan W L, Wei B W, et al. Heavy ions research facility in Lanzhou (HIRFL) (in Chinese). Chin Sci Bull, 2016, 4: 467−477 [夏佳文, 詹文龙, 魏宝文, 等. 兰州重离子加速器研究装置HIRFL. 科学通报 2016, 4: 467−477]&

[36] Liu Y R, Huang R Q, Xiao B K, et al. ¹H NMR metabolic profiling analysis offers evaluation of Nilestriol treatment in ovariectomised rats. Mol Cell Endocrinol, 2014, 387: 19–34. Google Scholar http://scholar.google.com/scholar_lookup?title=Liu Y R, Huang R Q, Xiao B K, et al. ¹H NMR metabolic profiling analysis offers evaluation of Nilestriol treatment in ovariectomised rats. Mol Cell Endocrinol, 2014, 387: 19–34&

[37] Akerman G S, Rosenzweig B A, Domon O E, et al. Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ Mol Mutagen, 2005, 45: 188-205 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells&author=Akerman G S&author=Rosenzweig B A&author=Domon O E&publication_year=2005&journal=Environ Mol Mutagen&volume=45&pages=188-205

[38] Koturbash I, Merrifield M, Kovalchuk O. Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner. Int J Radiat Biol, 2017, 93: 148-155 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner&author=Koturbash I&author=Merrifield M&author=Kovalchuk O&publication_year=2017&journal=Int J Radiat Biol&volume=93&pages=148-155

[39] Belousova E A, Kutuzov M M, Ivankina P A, et al. A new DNA break repair pathway involving PARP3 and base excision repair proteins. Dokl Biochem Biophys, 2018, 482: 233-237 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=A new DNA break repair pathway involving PARP3 and base excision repair proteins&author=Belousova E A&author=Kutuzov M M&author=Ivankina P A&publication_year=2018&journal=Dokl Biochem Biophys&volume=482&pages=233-237

[40] Fenton A L, Shirodkar P, Macrae C J, et al. The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair. Nucleic Acids Res, 2013, 41: 4080-4092 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair&author=Fenton A L&author=Shirodkar P&author=Macrae C J&publication_year=2013&journal=Nucleic Acids Res&volume=41&pages=4080-4092

[41] Mo L J, Song M, Huang Q H, et al. Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4. Br J Cancer, 2018, 119: 492-502 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4&author=Mo L J&author=Song M&author=Huang Q H&publication_year=2018&journal=Br J Cancer&volume=119&pages=492-502

[42] Jun S, Jung Y S, Suh H N, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun, 2016, 7: 10994 CrossRef PubMed Google Scholar http://scholar.google.com/scholar_lookup?title=LIG4 mediates Wnt signalling-induced radioresistance&author=Jun S&author=Jung Y S&author=Suh H N&publication_year=2016&journal=Nat Commun&volume=7&pages=10994